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Article

Are RASopathies new monogenic predisposing conditions to the development of systemic lupus erythematosus? Case report and systematic review of the literature.

Seminars in arthritis and rheumatism - 1 Oct 2013

Bader-Meunier Brigitte, Cavé Hélène, Jeremiah Nadia, Magerus Aude, Lanzarotti Nina, Rieux-Laucat Frédéric, Cormier-Daire Valérie

Abstract excerpt

OBJECTIVE: RASopathies (Noonan syndrome (NS) and Noonan-related syndromes) are neurodevelopmental syndromes resulting from germline mutations in genes that participate in the rat sarcoma/mitogen-activated protein kinases (RAS/MAPK) pathway (PTPN11, SOS1, RAF, KRAS or NRAS, and SHOC2). Some monogenic conditions are associated with the development of systemic lupus erythematosus (SLE), and a few reports described...

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Source

Identifiers

PMID: 23786871
DOI: 10.1016/j.semarthrit.2013.04.009

Genes

ACR
KRAS
NRAS
PTPN11
SOS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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