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Article

MUC1 induces drug resistance in pancreatic cancer cells via upregulation of multidrug resistance genes

17 Jun 2013

Abstract excerpt

MUC1 (CD227), a membrane tethered mucin glycoprotein, is overexpressed in >60% of human pancreatic cancers (PCs), and is associated with poor prognosis, enhanced metastasis and chemoresistance. The objective of this study was to delineate the mechanism by which MUC1 induces drug resistance in human (BxPC3 and Capan-1) and mouse (KCKO, KCM) PC cells. We report that PC cells that express high levels of MUC1 exhibit...

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PMID: 23774063
DOI: 10.1038/oncsis.2013.16

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