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Article

Gradients of Krüppel and knirps gene products direct pair-rule gene stripe patterning in the posterior region of the Drosophila embryo.

Cell - 20 Apr 1990

Pankratz M J, Seifert E, Gerwin N, Billi B, Nauber U, Jäckle H

Abstract excerpt

Abdominal segmentation of the Drosophila embryo requires the activities of the gap genes Krüppel (Kr), knirps (kni), and tailless (tll). They control the expression of the pair-rule gene hairy (h) by activating or repressing independent cis-acting units that generate individual stripes. Kr activates stripe 5 and represses stripe 6, kni activates stripe 6 and represses stripe 7, and tll activates stripe 7. Kr and...

Topics

Animals
DNA Probes
Drosophila
Embryo, Nonmammalian
Female
Gene Expression Regulation
Genes, Regulator
Mutation
Restriction Mapping

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2331752
DOI: 10.1016/0092-8674(90)90811-r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2331752-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Gradients of Krüppel and knirps gene products direct pair-rule gene stripe patterning in the posterior region of the Drosophila embryo.PMID 2331752Read ↗

Dose-dependent regulation of pair-rule stripes by gap proteins and the initiation of segment polarity.Semantic proximity Read ↗

A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo.Semantic proximity Read ↗

Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc.Semantic proximity Read ↗

Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes.Semantic proximity Read ↗

Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes.Semantic proximity Read ↗

cis-acting control elements for Krüppel expression in the Drosophila embryo.Semantic proximity Read ↗

Krüppel acts as a gap gene regulating expression of hunchback and even-skipped in the intermediate germ cricket Gryllus bimaculatus.Semantic proximity Read ↗

Quantitative dynamics and increased variability of segmentation gene expression in the Drosophila Krüppel and knirps mutants.Semantic proximity Read ↗

How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation.Semantic proximity Read ↗

Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo.Semantic proximity Read ↗

The knirps and knirps-related genes organize development of the second wing vein in Drosophila.Semantic proximity Read ↗

Dynamic patterning by the Drosophila pair-rule network reconciles long-germ and short-germ segmentation.Semantic proximity Read ↗

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