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Article

Global and gene-specific promoter methylation analysis in primary hyperparathyroidism

1 Jun 2013

Abstract excerpt

Epigenetic mechanisms involved in primary hyperparathyroidism are poorly understood as studies are limited. In order to understand the role of aberrant DNA promoter methylation in the pathogenesis of parathyroid tumors, we have quantified the CpG island promoter methylation density of several candidate genes including APC (promoter 1A and 1B), β-catenin (CTNNB1), CASR, CDC73/HRPT2, MEN1, P16 (CDKN2A), PAX1,...

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PMID: 23764768
DOI: 10.4161/epi.24823

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