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Article

Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants.

The Journal of biological chemistry - 26 Jul 2013

Antinone Sarah E, Ghadge Ghanashyam D, Lam Tukiet T, Wang Lijun, Roos Raymond P, Green William N

Abstract excerpt

Mutations in Cu,Zn-superoxide dismutase (mtSOD1) cause familial amyotrophic lateral sclerosis (FALS), a neurodegenerative disease resulting from motor neuron degeneration. Here, we demonstrate that wild type SOD1 (wtSOD1) undergoes palmitoylation, a reversible post-translational modification that can regulate protein structure, function, and localization. SOD1 palmitoylation was confirmed by multiple techniques,...

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Source

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Identifiers

PMID: 23760509
DOI: 10.1074/jbc.M113.487231
PMCID: PMC3724620

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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