Article
Long-term disability and prognosis in dentatorubral-pallidoluysian atrophy: a correlation with CAG repeat length.
Movement disorders : official journal of the Movement Disorder Society - 15 Aug 2010
Hasegawa Arika, Ikeuchi Takeshi, Koike Ryoko, Matsubara Nae, Tsuchiya Miyuki, Nozaki Hiroaki, Homma Atsushi, Idezuka Jiro, Nishizawa Masatoyo, Onodera Osamu
Abstract excerpt
Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare autosomal dominant neurodegenerative disorder caused by CAG repeat expansion. Previous studies demonstrated that the onset of DRPLA is closely associated with CAG repeat length. However, the natural history of DRPLA has not yet been evaluated. We here retrospectively investigated the factors that determine the disease milestones and prognosis in 183 Japanese...
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