Spontaneous high density lipoprotein deficiency syndrome associated with a Z-linked mutation in chickens.

Abstract excerpt

A mutant strain of chicken previously identified by a "recessive white skin" phenotype was found to have a profound deficiency in high density lipoprotein (HDL) and apolipoprotein A-I (apoA-I). ApoA-I levels in the mutant chickens were reduced by greater than 90%. Since HDL is the predominant cholesterol transporter in chickens, the HDL deficiency was associated with a greater than 80% decrease in total plasma...

Topics

• Animals
• Apolipoproteins A
• Chickens
• Disease Models, Animal
• Female
• Genotype
• Hypolipoproteinemias
• Lipoproteins, HDL
• Male
• Mutation
• Tangier Disease