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Article

Evolution of sex differences in lifespan and aging: causes and constraints.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Aug 2013

Maklakov Alexei A, Lummaa Virpi

Abstract excerpt

Why do the two sexes have different lifespans and rates of aging? Two hypotheses based on asymmetric inheritance of sex chromosomes ("unguarded X") or mitochondrial genomes ("mother's curse") explain sex differences in lifespan as sex-specific maladaptation leading to increased mortality in the shorter-lived sex. While asymmetric inheritance hypotheses equate long life with high fitness, considerable empirical...

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PMID: 23733656
DOI: 10.1002/bies.201300021

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