Non-mutagenic carcinogens are primarily hydrophobic.

doi:10.1093/carcin/11.7.1111

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Article

Non-mutagenic carcinogens are primarily hydrophobic.

Carcinogenesis - 1 Jul 1990

McCoy G D, Rosenkranz H S, Klopman G

Abstract excerpt

There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water...

Topics

Animals
Carcinogenicity Tests
Carcinogens
Chemical Phenomena
Chemistry
DNA
Mice
Mutagenicity Tests
Mutation
Rats

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