Non-mutagenic carcinogens are primarily hydrophobic.

Abstract excerpt

There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients than mutagenic ones. This property of non-mutagenic carcinogens may suggest that their ability...

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