Article
The preproghrelin 3056 TT genotype is associated with the feeling of hunger and low acylated ghrelin levels in Japanese patients with Helicobacter pylori-negative functional dyspepsia.
Internal medicine (Tokyo, Japan) - 1 Jan 2013
Futagami Seiji, Shimpuku Mayumi, Kawagoe Tetsuro, Izumi Nikki, Ohishi Noriko, Yamawaki Hiroshi, Shindo Tomotaka, Nagoya Hiroyuki, Horie Akane, Kodaka Yasuhiro, Gudis Katya, Itoh Takashi, Sakamoto Choitsu
Abstract excerpt
OBJECTIVE: An impairment of gastric motility is strongly associated with the pathophysiology of functional dyspepsia (FD). Plasma ghrelin is one of the key molecules linked to gastric motility. Therefore, this study aimed to evaluate whether ghrelin (GHRL) gene polymorphisms are associated with clinical symptoms, the plasma ghrelin levels and gastric emptying in patients with FD as defined by the Rome III...
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