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Article

Adaptation to tert-butyl hydroperoxide at a plasma membrane level in the fission yeast Schizosaccharomyces pombe parental strain and its t-BuOOH-resistant mutant.

Journal of basic microbiology - 1 Mar 2014

Kálmán Nikoletta, Gazdag Zoltán, Čertík Milan, Belágyi József, Selim Samy A, Pócsi István, Pesti Miklós

Abstract excerpt

The one-gene mutant hyd1-190 of the fission yeast Schizosaccharomyces pombe displayed four-fold resistance to tert-butyl hydroperoxide (t-BuOOH) in comparison with its parental strain hyd(+). The cells of hyd1-190 exhibited a quantitative alteration in the sterol content and hence in the fatty acid composition of the plasma membrane, reflected in a two-fold amphotericin B sensitivity, increased rigidity of the...

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PMID: 23712692
DOI: 10.1002/jobm.201200580

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