Altered plasma membrane H(+)-ATPase from the Dio-9-resistant pma1-2 mutant of Schizosaccharomyces pombe.

doi:10.1111/j.1432-1033.1992.tb17286.x

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Article

Altered plasma membrane H(+)-ATPase from the Dio-9-resistant pma1-2 mutant of Schizosaccharomyces pombe.

European journal of biochemistry - 1 Oct 1992

Ghislain M, De Sadeleer M, Goffeau A

Abstract excerpt

The pma1-2 mutation affecting the plasma membrane H(+)-ATPase of Schizosaccharomyces pombe has been selected for resistance to the antibiotic Dio-9. In membrane fractions purified from glucose-starved cells, the mutant ATPase activity is reduced by 96%, is insensitive to inhibition by vanadate an...

Topics

Cell Membrane
Drug Resistance, Microbial
Enzyme Activation
Glucose
Glycine
Hydrogen-Ion Concentration
Lysine
Mutation
Organic Chemicals
Proton-Translocating ATPases
Schizosaccharomyces
Uncoupling Agents
Vanadates

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