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Article

miR-10a restores human mesenchymal stem cell differentiation by repressing KLF4.

Journal of cellular physiology - 1 Dec 2013

Li Jiao, Dong Jun, Zhang Zhen-Hui, Zhang Dong-Cheng, You Xiang-Yu, Zhong Yun, Chen Min-Sheng, Liu Shi-Ming

Abstract excerpt

miRNAs have recently been shown to play a significant role in human aging. However, data demonstrating the effects of aging-related miRNAs in human mesenchymal stem cells (hMSCs) are limited. We observed that hMSC differentiation decreased with aging. We also identified that miR-10a expression was significantly decreased with age by comparing the miRNA expression of hMSCs derived from young and aged individuals....

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Identifiers

PMID: 23696417
DOI: 10.1002/jcp.24402
PMCID: PMC4285942

Genes

KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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