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Article

Skeletal muscle ATP kinetics are impaired in frail mice.

Age (Dordrecht, Netherlands) - 1 Feb 2014

Akki Ashwin, Yang Huanle, Gupta Ashish, Chacko Vadappuram P, Yano Toshiyuki, Leppo Michelle K, Steenbergen Charles, Walston Jeremy, Weiss Robert G

Abstract excerpt

The interleukin-10 knockout mouse (IL10(tm/tm)) has been proposed as a model for human frailty, a geriatric syndrome characterized by skeletal muscle (SM) weakness, because it develops an age-related decline in SM strength compared to control (C57BL/6J) mice. Compromised energy metabolism and energy deprivation appear to play a central role in muscle weakness in metabolic myopathies and muscular dystrophies....

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Source

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Identifiers

PMID: 23695949
DOI: 10.1007/s11357-013-9540-0
PMCID: PMC3889887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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