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Article

Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin.

Journal of basic microbiology - 1 Apr 2014

Olesen Sanne H, Ingles Donna J, Yang Yan, Schönbrunn Ernst

Abstract excerpt

Terreic acid is a metabolite with antibiotic properties produced by the fungus Aspergillus terreus, but its cellular target remains unknown. We recently reported that terreic acid inactivates the bacterial cell wall biosynthetic enzyme MurA in vitro by covalent reaction with residue Cys115 in a similar manner as the MurA-specific antibiotic fosfomycin. To address if terreic acid also targets MurA in vivo, we...

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Identifiers

PMID: 23686727
DOI: 10.1002/jobm.201200617
PMCID: PMC4610358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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