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Article

Role of the intradiscal domain in rhodopsin assembly and function.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990

Doi T, Molday R S, Khorana H G

Abstract excerpt

The role of the intradiscal polypeptide loops in bovine rhodopsin has been investigated by deletions in the N-terminal tail and in loops B-C, D-E, and E-F as well as by single amino acid substitutions in the D-E loop. Mutants with three types of phenotypes were observed. Type I mutants showed a rhodopsin-like chromophore and glycosylation. Type II mutants did not regenerate the chromophore and showed abnormal...

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Identifiers

PMID: 2367520
DOI: 10.1073/pnas.87.13.4991
PMCID: PMC54247

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