Article
Role of the intradiscal domain in rhodopsin assembly and function.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Doi T, Molday R S, Khorana H G
Abstract excerpt
The role of the intradiscal polypeptide loops in bovine rhodopsin has been investigated by deletions in the N-terminal tail and in loops B-C, D-E, and E-F as well as by single amino acid substitutions in the D-E loop. Mutants with three types of phenotypes were observed. Type I mutants showed a rhodopsin-like chromophore and glycosylation. Type II mutants did not regenerate the chromophore and showed abnormal...
Topics
- Amino Acid Sequence
- Animals
- Cattle
- Cell Line
- Gene Expression
- Genes
- Glycosylation
- Kinetics
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Phenotype