Article
Primary cilia in gastric gastrointestinal stromal tumours (GISTs): an ultrastructural study.
Journal of cellular and molecular medicine - 1 Jul 2013
Castiella Tomás, Muñoz Guillermo, Luesma María José, Santander Sonia, Soriano Mario, Junquera Concepción
Abstract excerpt
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal (non-epithelial) neoplasms of the human gastrointestinal (GI) tract. They are thought to derive from interstitial cells of Cajal (ICCs) or an ICC progenitor based on immunophenotypical and ultrastructural similarities. Because ICCs show primary cilium, our hypothesis is based on the possibility that some of these neoplastic cells could also...
Topics
- Actins
- Antigens, CD34
- Biomarkers, Tumor
- Cilia
- Cytoplasm
- Desmin
- Gastrointestinal Neoplasms
- Gastrointestinal Stromal Tumors
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Immunophenotyping