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Article

The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations.

Human molecular genetics - 15 Sept 2013

Dunmore Benjamin J, Drake Kylie M, Upton Paul D, Toshner Mark R, Aldred Micheala A, Morrell Nicholas W

Abstract excerpt

Pulmonary arterial hypertension (PAH) is characterized by dysregulated pulmonary artery endothelial cell (PAEC) proliferation, apoptosis and permeability. Loss-of-function mutations in the bone morphogenetic protein receptor type-II (BMPR-II) are the most common cause of heritable PAH, usually re...

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Source

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Identifiers

PMID: 23669347
DOI: 10.1093/hmg/ddt216
PMCID: PMC3749859

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23669347-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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