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Engineering T Cell Function Using Chimeric Antigen Receptors Identified Using a DNA Library Approach

7 May 2013

Abstract excerpt

Genetic engineering of cellular function holds much promise for the treatment of a variety of diseases including gene deficiencies and cancer. However, engineering the full complement of cellular functions can be a daunting genetic exercise since many molecular triggers need to be activated to achieve complete function. In the case of T cells, genes encoding chimeric antigen receptors (CARs) covalently linking...

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PMID: 23667569
DOI: 10.1371/journal.pone.0063037

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