Article
Fine localization of the CMT4A locus using a PAC contig and haplotype analysis.
Neurogenetics - 1 Dec 1998
Ben Othmane K, Rochelle J M, Ben Hamida M, Slotterbeck B, Rao N, Hentati F, Pericak-Vance M A, Vance J M
Abstract excerpt
Charcot-Marie-Tooth disease type 4A (CMT4A) is a severe, autosomal recessive peripheral neuropathy linked to chromosome 8q13-q21. We have previously constructed a YAC contig across the CMT4A region and narrowed the disease-flanking interval to approximately three megabases. Subsequently, we const...
Topics
- Alleles
- Base Sequence
- Charcot-Marie-Tooth Disease
- Chromosome Mapping
- Chromosomes, Human, Pair 8
- Contig Mapping
- DNA Fingerprinting
- DNA Primers
- Genetic Markers
- Haplotypes
- Humans
- Microsatellite Repeats
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational