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Article

c-MYC-regulated miR-23a/24-2/27a cluster promotes mammary carcinoma cell invasion and hepatic metastasis by targeting Sprouty2.

The Journal of biological chemistry - 21 Jun 2013

Li Xiaoni, Liu Xin, Xu Weiyi, Zhou Peng, Gao Ping, Jiang Songshan, Lobie Peter E, Zhu Tao

Abstract excerpt

Emerging evidence indicates that the miR-23a/24-2/27a cluster may possess a causal role in mammary tumorigenesis and function as a novel class of oncogenes. However, the regulatory mechanism of the miR-23a/24-2/27a cluster in mammary carcinoma cell invasion and migration is still largely unknown. We observed that the expression levels of miR-23a, miR-24-2 and miR-27a were significantly higher in breast cancer...

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Share to Epidermal Growth Factor
Share to Mammary Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MCF-7 Cells

Share to Mice, Nude

Share to Mitogen-Activated Protein Kinases

Share to Neoplasm Invasiveness

Share to Proto-Oncogene Proteins c-myc

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Source

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Identifiers

PMID: 23649631
DOI: 10.1074/jbc.M113.478560
PMCID: PMC3689956

Genes

MYC
SPRY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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