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Article

[Structural study of polyglutamine tract-binding protein 1].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Jan 2013

Mizuguchi Mineyuki, Okazawa Hitoshi

Abstract excerpt

Polyglutamine tract-binding protein 1 (PQBP1) is a nuclear protein that regulates transcription and pre-mRNA splicing. In addition, the mutations in the PQBP1 gene are known to cause hereditary mental retardation. This review summarizes current knowledge about the solution structure of PQBP1. PQBP1 is an intrinsically disordered protein: its polar-rich domain and C-terminal domain are disordered under...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23649393
DOI: 10.1248/yakushi.13-00001-2

Genes

PQBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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[Structural study of polyglutamine tract-binding protein 1].PMID 23649393Read ↗

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SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesisSemantic proximity Read ↗

Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction.Semantic proximity Read ↗

Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation.Semantic proximity Read ↗

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