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Article

Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 2013

Kempadoo Kimberly A, Tourino Clara, Cho Saemi L, Magnani Francesco, Leinninger Gina-Marie, Stuber Garret D, Zhang Feng, Myers Martin G, Deisseroth Karl, de Lecea Luis, Bonci Antonello

Abstract excerpt

The lateral hypothalamus (LH) sends a dense glutamatergic and peptidergic projection to dopamine neurons in the ventral tegmental area (VTA), a cell group known to promote reinforcement and aspects of reward. The role of the LH to VTA projection in reward-seeking behavior can be informed by using optogenetic techniques to dissociate the actions of LH neurons from those of other descending forebrain inputs to the...

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Identifiers

PMID: 23637156
DOI: 10.1523/JNEUROSCI.2588-12.2013
PMCID: PMC3865559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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