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Article

Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegeneration.

PloS one - 1 Jan 2013

Lin Yunting, Tang Chengyuan, He Hua, Duan Ranhui

Abstract excerpt

Fragile X associated tremor/ataxia syndrome (FXTAS) is a late onset neurodegenerative disorder caused by aberrant expansion of CGG repeats in 5' UTR of FMR1 gene. The elevated mRNA confers a toxic gain-of-function thought to be the critical event of pathogenesis. Expressing rCGG90 repeats of the human FMR1 5'UTR in Drosophila is sufficient to induce neurodegeneration. Rapamycin has been demonstrated to attenuate...

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Source

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Identifiers

PMID: 23626835
DOI: 10.1371/journal.pone.0062572
PMCID: PMC3633886

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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