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Article

Germline and somatic DICER1 mutations in familial and sporadic liver tumors.

Journal of hepatology - 1 Apr 2017

Caruso Stefano, Calderaro Julien, Letouzé Eric, Nault Jean-Charles, Couchy Gabrielle, Boulai Anaïs, Luciani Alain, Zafrani Elie-Serge, Bioulac-Sage Paulette, Seror Olivier, Imbeaud Sandrine, Zucman-Rossi Jessica

Abstract excerpt

BACKGROUND & AIMS: Growing evidence suggests that genetic predisposition significantly increases the risk of hepatocellular carcinoma (HCC), independently from the presence of other risk factors. Here, we report a novel germline DICER1 mutation associated with familial recurrent liver tumors. We then aimed to investigate the contribution of constitutional and somatic DICER1 mutations on HCC occurrence. METHODS:...

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Share to Neoplasm Recurrence, Local
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Carcinoma, Hepatocellular

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Source

Identifiers

PMID: 28012864
DOI: 10.1016/j.jhep.2016.12.010

Genes

DICER1
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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