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Article

Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors.

Cancer - 15 Aug 2012

Kim Woo-Young, Prudkin Ludmila, Feng Lei, Kim Edward S, Hennessy Bryan, Lee Ju-Seog, Lee J Jack, Glisson Bonnie, Lippman Scott M, Wistuba Ignacio I, Hong Waun Ki, Lee Ho-Young

Abstract excerpt

BACKGROUND: Most patients with nonsmall cell lung cancer (NSCLC) have responded poorly to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). The authors investigated the involvement of insulinlike growth factor 1 receptor (IGF-1R) signaling in primary resistance to EGFR TKIs and the molecular determinants of resistance to IGF-1R TKIs. METHODS: Phosphorylated IGF-1R/insulin receptor...

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Identifiers

PMID: 22359227
DOI: 10.1002/cncr.26656
PMCID: PMC3674414

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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