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Article

Interaction of Hb adana (HBA2: c.179G>A) with deletional and nondeletional α(+)-thalassemia mutations: diverse hematological and clinical features.

Hemoglobin - 1 Jan 2013

Nainggolan Ita M, Harahap Alida, Ambarwati Debby D, Liliani Rosalina V, Megawati Dewi, Swastika Maria, Setianingsih Iswari

Abstract excerpt

We describe 27 cases of mild-to-severe α-thalassemia (α-thal) syndrome caused by interaction of Hb Adana [α59(E8)Gly→Asp, GGC>GAC (α2)] with deletional and nondeletional α(+)-thal mutations in Indonesian patients. Hematological profiles and clinical manifestations of all patients were assessed by routine procedures. The genotypes were generated by a multiplex-polymerase chain reaction (m-PCR), PCR-RFLP...

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Identifiers

PMID: 23614625
DOI: 10.3109/03630269.2013.775149
PMCID: PMC3667679

Genes

HBA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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