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Article

Ligand binding and aggregation of pathogenic SOD1.

Nature communications - 1 Jan 2013

Wright Gareth S A, Antonyuk Svetlana V, Kershaw Neil M, Strange Richard W, Samar Hasnain S

Abstract excerpt

Mutations in the gene encoding Cu/Zn superoxide dismutase-1 cause amyotrophic lateral sclerosis. Superoxide dismutase-1 mutations decrease protein stability and promote aggregation. The mutant monomer is thought to be an intermediate in the pathway from the superoxide dismutase-1 dimer to aggrega...

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Identifiers

PMID: 23612299
DOI: 10.1038/ncomms2750
PMCID: PMC3644087

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23612299-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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