Article
The stability of cylindrin β-barrel amyloid oligomer models-a molecular dynamics study.
Proteins - 1 Sept 2013
Berhanu Workalemahu M, Hansmann Ulrich H E
Abstract excerpt
Small-soluble amyloid oligomers are believed to play a significant role in the pathology of amyloid diseases. Recently, the atomic structure of a toxic oligomer formed by an 11 residue and its tandem repeat was found to have an out-off register antiparallel β-strands in the shape of a β-barrel. In the present article we investigate the effect of mutations in the hydrophobic cores on the structure and dynamic of...
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