Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mediating Resistance in Oncogene-Driven Cancers

17 Apr 2013

Abstract excerpt

Resistance to drugs that shut down oncoprotein-driven pathways can occur because of compensatory changes in connecting pathways. Loss of expression of MED12, which acts in the TGFβ signaling pathway, may mediate resistance to gefitinib and vemurafenib.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lung Cancer Treatments and Mutations
Share to Pancreatic and Hepatic Oncology Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23594009
DOI: 10.1056/nejmcibr1214549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mediating Resistance in Oncogene-Driven CancersPMID 23594009Read ↗

Mapping the Pathways of Resistance to Targeted TherapiesSemantic proximity Read ↗

Targeting oncogene dependence and resistance.Semantic proximity Read ↗

Cancer therapy based on oncogene addictionSemantic proximity Read ↗

Mechanisms of targeted therapy resistance take a de-TOR.Semantic proximity Read ↗

MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor SignalingSemantic proximity Read ↗

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanismsSemantic proximity Read ↗

Mechanisms of resistance to ErbB-targeted cancer therapeutics.Semantic proximity Read ↗

Crosstalk in cancer resistance and metastasisSemantic proximity Read ↗

Overcoming resistance to tyrosine kinase inhibitors: Lessons learned from cancer cells treated with EGFR antagonistsSemantic proximity Read ↗

[Mechanisms of resistance to crizotinib in patients with transforming EML4-ALK fusion gene].Semantic proximity Read ↗

TGF-β mediated drug resistance in solid cancerSemantic proximity Read ↗

Reversing Drug Resistance In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.