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Article

Assessing the effects of Aedes aegypti kdr mutations on pyrethroid resistance and its fitness cost.

PloS one - 1 Jan 2013

Brito Luiz Paulo, Linss Jutta G B, Lima-Camara Tamara N, Belinato Thiago A, Peixoto Alexandre A, Lima José Bento P, Valle Denise, Martins Ademir J

Abstract excerpt

Pyrethroids are the most used insecticide class worldwide. They target the voltage gated sodium channel (NaV), inducing the knockdown effect. In Aedes aegypti, the main dengue vector, the AaNaV substitutions Val1016Ile and Phe1534Cys are the most important knockdown resistance (kdr) mutations. We evaluated the fitness cost of these kdr mutations related to distinct aspects of development and reproduction, in the...

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PMID: 23593337
DOI: 10.1371/journal.pone.0060878
PMCID: PMC3620451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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