Article
Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence.
PLoS pathogens - 1 Jan 2013
Kaito Chikara, Saito Yuki, Ikuo Mariko, Omae Yosuke, Mao Han, Nagano Gentaro, Fujiyuki Tomoko, Numata Shunsuke, Han Xiao, Obata Kazuaki, Hasegawa Setsuo, Yamaguchi Hiroki, Inokuchi Koiti, Ito Teruyo, Hiramatsu Keiichi, Sekimizu Kazuhisa
Abstract excerpt
Community acquired-methicillin resistant Staphylococcus aureus (CA-MRSA) is a socially problematic pathogen that infects healthy individuals, causing severe disease. CA-MRSA is more virulent than hospital associated-MRSA (HA-MRSA). The underlying mechanism for the high virulence of CA-MRSA is not known. The transcription product of the psm-mec gene, located in the mobile genetic element SCCmec of HA-MRSA, but not...
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