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Article

A colorectal cancer classification system that associates cellular phenotype and responses to therapy.

Nature medicine - 1 May 2013

Sadanandam Anguraj, Lyssiotis Costas A, Homicsko Krisztian, Collisson Eric A, Gibb William J, Wullschleger Stephan, Ostos Liliane C Gonzalez, Lannon William A, Grotzinger Carsten, Del Rio Maguy, Lhermitte Benoit, Olshen Adam B, Wiedenmann Bertram, Cantley Lewis C, Gray Joe W, Hanahan Douglas

Abstract excerpt

Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 CRC tumors using consensus-based unsupervised clustering. The resultant clusters were then associated with therapeutic response data to the epidermal growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23584089
DOI: 10.1038/nm.3175
PMCID: PMC3774607

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