Article
The sequences of 150,119 genomes in the UK Biobank.
Nature - 1 Jul 2022
Halldorsson Bjarni V, Eggertsson Hannes P, Moore Kristjan H S, Hauswedell Hannes, Eiriksson Ogmundur, Ulfarsson Magnus O, Palsson Gunnar, Hardarson Marteinn T, Oddsson Asmundur, Jensson Brynjar O, Kristmundsdottir Snaedis, Sigurpalsdottir Brynja D, Stefansson Olafur A, Beyter Doruk, Holley Guillaume, Tragante Vinicius, Gylfason Arnaldur, Olason Pall I, Zink Florian, Asgeirsdottir Margret, Sverrisson Sverrir T, Sigurdsson Brynjar, Gudjonsson Sigurjon A, Sigurdsson Gunnar T, Halldorsson Gisli H, Sveinbjornsson Gardar, Norland Kristjan, Styrkarsdottir Unnur, Magnusdottir Droplaug N, Snorradottir Steinunn, Kristinsson Kari, Sobech Emilia, Jonsson Helgi, Geirsson Arni J, Olafsson Isleifur, Jonsson Palmi, Pedersen Ole Birger, Erikstrup Christian, Brunak Søren, Ostrowski Sisse Rye, Thorleifsson Gudmar, Jonsson Frosti, Melsted Pall, Jonsdottir Ingileif, Rafnar Thorunn, Holm Hilma, Stefansson Hreinn, Saemundsdottir Jona, Gudbjartsson Daniel F, Magnusson Olafur T, Masson Gisli, Thorsteinsdottir Unnur, Helgason Agnar, Jonsson Hakon, Sulem Patrick, Stefansson Kari
Abstract excerpt
Detailed knowledge of how diversity in the sequence of the human genome affects phenotypic diversity depends on a comprehensive and reliable characterization of both sequences and phenotypic variation. Over the past decade, insights into this relationship have been obtained from whole-exome sequencing or whole-genome sequencing of large cohorts with rich phenotypic data1,2. Here we describe the analysis of...
Topics
- Africa
- Asia
- Biological Specimen Banks
- Cohort Studies