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Riding the crest of the wave: parallels between the neural crest and cancer in epithelial‐to‐mesenchymal transition and migration

10 Apr 2013

Abstract excerpt

The neural crest (NC) is first induced as an epithelial population of cells at the neural plate border requiring complex signaling between bone morphogenetic protein, Wnt, and fibroblast growth factors to differentiate the neural and NC fate from the epidermis. Remarkably, following induction, these cells undergo an epithelial-to-mesenchymal transition (EMT), delaminate from the neural tube, and migrate through...

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PMID: 23576382
DOI: 10.1002/wsbm.1224

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