Article
Haptoglobin phenotype, preeclampsia risk and the efficacy of vitamin C and E supplementation to prevent preeclampsia in a racially diverse population.
PloS one - 1 Jan 2013
Weissgerber Tracey L, Gandley Robin E, McGee Paula L, Spong Catherine Y, Myatt Leslie, Leveno Kenneth J, Thorp John M, Mercer Brian M, Peaceman Alan M, Ramin Susan M, Carpenter Marshall W, Samuels Philip, Sciscione Anthony, Harper Margaret, Tolosa Jorge E, Saade George, Sorokin Yoram
Abstract excerpt
Haptoglobin's (Hp) antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular disease risk and treatment response to antioxidant vitamins in some non-pregnant populations. We previously demonstrated that preeclampsia risk was doubled in white Hp 2-1 women, compared to Hp 1-1 women. Our objectives were to determine whether we could reproduce this...
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