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Article

Molecular Karyotyping of Human Single Sperm by Array- Comparative Genomic Hybridization

2 Apr 2013

Abstract excerpt

No valid method is currently available to analyze the entire genome of sperm, including aneuploidies and structural chromosomal alterations. Here we describe the optimization and application of array-Comparative Genomic Hybridization (aCGH) on single human sperm. The aCGH procedure involves screening of the entire chromosome complement by DNA microarray allowing having a molecular karyotype, and it is currently...

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Share to Chromosomal and Genetic Variations
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Share to Prenatal Screening and Diagnostics

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PMID: 23565289
DOI: 10.1371/journal.pone.0060922

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