Article
E47 and Id1 interplay in epithelial-mesenchymal transition.
PloS one - 1 Jan 2013
Cubillo Eva, Diaz-Lopez Antonio, Cuevas Eva P, Moreno-Bueno Gema, Peinado Hector, Montes Amalia, Santos Vanesa, Portillo Francisco, Cano Amparo
Abstract excerpt
E12/E47 proteins (encoded by E2A gene) are members of the class I basic helix-loop-helix (bHLH) transcription factors (also known as E proteins). E47 has been described as repressor of E-cadherin and inducer of epithelial-mesenchymal transition (EMT). We reported previously that EMT mediated by E47 in MDCK cells occurs with a concomitant overexpression of Id1 and Id3 proteins. Id proteins belong to class V of HLH...
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