Article
MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation.
The Journal of clinical investigation - 1 May 2013
Luo Xiaobin, Pan Zhenwei, Shan Hongli, Xiao Jiening, Sun Xuelin, Wang Ning, Lin Huixian, Xiao Ling, Maguy Ange, Qi Xiao-Yan, Li Yue, Gao Xu, Dong Deli, Zhang Yong, Bai Yunlong, Ai Jing, Sun Lihua, Lu Hang, Luo Xiao-Yan, Wang Zhiguo, Lu Yanjie, Yang Baofeng, Nattel Stanley
Abstract excerpt
Atrial fibrillation (AF) is a highly prevalent arrhythmia with pronounced morbidity and mortality. Inward-rectifier K+ current (IK1) is believed to be an important regulator of reentrant-spiral dynamics and a major component of AF-related electrical remodeling. MicroRNA-26 (miR-26) is predicted to target the gene encoding KIR2.1, KCNJ2. We found that miR-26 was downregulated in atrial samples from AF animals and...
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