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Article

Plants regenerated from tissue culture contain stable epigenome changes in rice.

eLife - 19 Mar 2013

Stroud Hume, Ding Bo, Simon Stacey A, Feng Suhua, Bellizzi Maria, Pellegrini Matteo, Wang Guo-Liang, Meyers Blake C, Jacobsen Steven E

Abstract excerpt

Most transgenic crops are produced through tissue culture. The impact of utilizing such methods on the plant epigenome is poorly understood. Here we generated whole-genome, single-nucleotide resolution maps of DNA methylation in several regenerated rice lines. We found that all tested regenerated plants had significant losses of methylation compared to non-regenerated plants. Loss of methylation was largely...

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Identifiers

PMID: 23539454
DOI: 10.7554/eLife.00354
PMCID: PMC3601819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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