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Article

One-pot multi-enzyme (OPME) chemoenzymatic synthesis of sialyl-Tn-MUC1 and sialyl-T-MUC1 glycopeptides containing natural or non-natural sialic acid.

Bioorganic & medicinal chemistry - 15 Aug 2013

Malekan Hamed, Fung Gabriel, Thon Vireak, Khedri Zahra, Yu Hai, Qu Jingyao, Li Yanhong, Ding Li, Lam Kit S, Chen Xi

Abstract excerpt

A series of STn-MUC1 and ST-MUC1 glycopeptides containing naturally occurring and non-natural sialic acids have been chemoenzymatically synthesized from Tn-MUC1 glycopeptide using one-pot multienzyme (OPME) approaches. In situ generation of the sialyltransferase donor cytidine 5'-monophosphate-si...

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Source

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Identifiers

PMID: 23535562
DOI: 10.1016/j.bmc.2013.02.040
PMCID: PMC3722252

Genes

MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23535562-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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