Article
Continuing difficulties in interpreting CNV data: lessons from a genome-wide CNV association study of Australian HNPCC/lynch syndrome patients.
BMC medical genomics - 26 Mar 2013
Talseth-Palmer Bente A, Holliday Elizabeth G, Evans Tiffany-Jane, McEvoy Mark, Attia John, Grice Desma M, Masson Amy L, Meldrum Cliff, Spigelman Allan, Scott Rodney J
Abstract excerpt
BACKGROUND: Hereditary non-polyposis colorectal cancer (HNPCC)/Lynch syndrome (LS) is a cancer syndrome characterised by early-onset epithelial cancers, especially colorectal cancer (CRC) and endometrial cancer. The aim of the current study was to use SNP-array technology to identify genomic aberrations which could contribute to the increased risk of cancer in HNPCC/LS patients. METHODS: Individuals diagnosed...
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