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Article

A yeast chemical genetic screen identifies inhibitors of human telomerase.

Chemistry & biology - 21 Mar 2013

Wong Lai Hong, Unciti-Broceta Asier, Spitzer Michaela, White Rachel, Tyers Mike, Harrington Lea

Abstract excerpt

Telomerase comprises a reverse transcriptase and an internal RNA template that maintains telomeres in many eukaryotes, and it is a well-validated cancer target. However, there is a dearth of small molecules with efficacy against human telomerase in vivo. We developed a surrogate yeast high-throughput assay to identify human telomerase inhibitors. The reversibility of growth arrest induced by active human...

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Identifiers

PMID: 23521791
DOI: 10.1016/j.chembiol.2012.12.008
PMCID: PMC3650558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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