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Article

A concanavalin A-like lectin domain in the CHS1/LYST protein, shared by members of the BEACH family

16 Mar 2009

Abstract excerpt

CHS1/LYST, the causative protein of the Chediak-Higashi syndrome (CHS), belongs to the BEACH (named after BEige And Chediak-Higashi) family, which includes various large proteins sharing the same C-terminal domain architecture [a PH (Pleckstrin homology)-BEACH domain followed by WD repeats). Members of the BEACH family are generally defined as vesicle-trafficking regulatory proteins, but their functions remain to...

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PMID: 19289442
DOI: 10.1093/bioinformatics/btp151

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