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Article

Nanog Is an Essential Factor for Induction of Pluripotency in Somatic Cells from Endangered Felids

22 Jan 2013

Abstract excerpt

Nanog has an important role in pluripotency induction in bovines and snow leopards. To examine whether it was required for wild felids globally, we examined the induction of pluripotency in felids from Asia (Bengal tiger, Panthera tigris), Africa (serval, Leptailurus serval), and the Americas (jaguar, Panthera onca). Dermal fibroblasts were transduced with genes encoding the human transcription factors OCT4,...

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PMID: 23514873
DOI: 10.1089/biores.2012.0297

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