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Nanoparticle-mediated Gene Silencing Confers Radioprotection to Salivary Glands In Vivo

19 Mar 2013

Abstract excerpt

Radiation treatment of head and neck cancers causes irreversible damage of the salivary glands (SG). Here, we introduce a preclinical mouse model for small-interfering RNA (siRNA)-based gene silencing to provide protection of SG from radiation-induced apoptosis. Novel, pH-responsive nanoparticles complexed with siRNAs were introduced into mouse submandibular glands (SMG) by retroductal injection to modulate gene...

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PMID: 23511246
DOI: 10.1038/mt.2013.42

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