Article
Evidence for Ca(2+)-regulated ATP release in gastrointestinal stromal tumors.
Experimental cell research - 1 May 2013
Berglund Erik, Berglund David, Akcakaya Pinar, Ghaderi Mehran, Daré Elisabetta, Berggren Per-Olof, Köhler Martin, Aspinwall Craig A, Lui Weng-Onn, Zedenius Jan, Larsson Catharina, Bränström Robert
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are thought to originate from the electrically active pacemaker cells of the gastrointestinal tract. Despite the presence of synaptic-like vesicles and proteins involved in cell secretion it remains unclear whether GIST cells possess regulated release mechanisms. The GIST tumor cell line GIST882 was used as a model cell system, and stimulus-release coupling was investigated...
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