Article
Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.
Annals of neurology - 1 Jul 2013
Engeln Michel, Fasano Stefania, Ahmed Serge H, Cador Martine, Baekelandt Veerle, Bezard Erwan, Fernagut Pierre-Olivier
Abstract excerpt
Dopamine dysregulation syndrome shares some core behavioral features with psychostimulant addiction, suggesting that dopamine replacement therapy can acquire psychostimulantlike properties in some patients with Parkinson disease (PD). We here report strong experimental evidence supporting this hypothesis in an α-synuclein rat model of PD. Although levodopa had no effect in controls, it acquired 2 prominent...
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