Article
Endocannabinoid system and drug addiction: new insights from mutant mice approaches.
Current opinion in neurobiology - 1 Aug 2013
Maldonado Rafael, Robledo Patricia, Berrendero Fernando
Abstract excerpt
The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabinoid system components has now provided important advances in establishing their specific...
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