Genome-Wide Screening Reveals That miR-195 Targets the TNF-α/NF-κB Pathway by Down-Regulating IΚB Kinase Alpha and TAB3 in Hepatocellular Carcinoma

Abstract excerpt

UNLABELLED: Nuclear factor kappa B (NF-κB) is an important factor linking inflammation and tumorigenesis. In this study we experimentally demonstrated through a high-throughput luciferase reporter screen that NF-κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF-κB signaling nodes by binding to their 3' untranslated region (UTR). miR-195, a member of...

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